Clementine is a lab mouse with super intelligence. She was rescued by a junior researcher and placed in the mailbox of a nature tv show host, Pop, and his grandson. The lab is offering rewards for her capture so they devise a plan to have Clementine play chess on the show to save her life. Written in letter format from Clementine to a chimpanzee lab friend, Rosie, Always, Clementine is heartwarming and heartbreaking all at once.