I read this a few years ago and thought the system and techniques had the potential to be incredible, but felt a literal application of them may feel too much like an accountant with OCD. Applying the methodology outlined in this book along with some of the fine-tuning applied by people like Merlin Mann (and others) may lead to a more workable solutions.

Either way, I strongly recommend this book as an introduction to the concepts of brain-dumping your responsibilities into a system (any system that works for you) that then refreshes and reminds you as appropriate. No matter how much of a steel trap you think your memory is... it isn't.