I really wanted to like this book. I found the premise interesting and was intruigued to learn more about the lives of Native Americans, but I found the book too confusing and the characters not well-rounded enough for me to distinguish some of them from one another. I had to keep flicking back to earlier in the book to see if I had met this character before, heard about them from another character, or whether they were a new person suddenly injected into the story three-quarters of the way in. It didn't help that a character referred to as David by another character actually was called Daniel when we met him properly.
The idea of meeting all these characters who are interlinked with one another in their own chapter was similar to the concept in Bernardine Evaristo's Girl, Woman, Other, but it worked much better for me in that book than in There, There. Evaristo's characters seemed more fully rounded and I cared far more about them than Tommy Orange's. Perhaps this was also because the majority of characters in Girl, Woman, Other are women or identify as women and so I could understand them better almost immediately and that helped me to warm to them more. I did find the three women in Tommy Orange's story much easier to identify with than any of the male characters. 
According to the blurb, we meet 12 characters in There, There, but to me it felt like at least 20-25 as I struggled to recognise them. And I felt short-changed by how much he delved into some of the characters that I did really like, such as Dene Oxendene.