The short story in the title itself has a special charm with touching such sensitive themes, yet it's more important in the sense of showing how a way of a completely artifical world could work, how could an artifical reality reach actuality through not having any kind of "exit" by the senses or even ideas. Almost everything in a human being can be altered in a way or other.

In my opinion, the aspect of a depicted Artifical Intelligence itself is very science fiction here, but the unsetting and disturbing aspect is sensing how much we rely on perception itself, how fragile our memory and body is especially compared to computers. What and why AM does in the story is science fiction. How AM does everything however, is not.

Ellison is truly a fascinating author, he clearly doesn't care about any genre, origin or even science-fiction in general, only ideas and mythology as he clearly states it in a few commentaries. You owe yourself a favor to read some of his stories, including the one in the title of this collection. All of the stories are truly clever pieces even if with less power than "I Have No Mouth", but that's only because they don't deal with such fundamental and existential horror like the mentioned title.

About misogyny, you should consider the comments of the author himself: "When people are at their worst, they are the most interesting."